uri icon
  • Contact Info
  • 202-994-5029

Xin Wang Faculty Member

Positions

During the academic year April to December 2021, I have collected strong imaging and electrophysiology data to support the manuscript “Activation of leptin receptor positive neurons in dorsomedial hypothalamus stimulates breathing in obese mice”. I have made good progress in trouble shooting: adjusting dissection orientation to obtain brain slices that contain sufficient neural pathway connections between two separate and long-distance neuron populations for electrophysiology study, patch clamp neurons successfully in old animal, and IHC staining to identify the specific 5HT cells. Our finding confirms that central Leptin receptor-b (LepR+) containing neurons project extensively to the serotonin neurons in different areas including midbrain and medulla. Optogenetic activation of LepR+ ChR2 positive fibers in the dorsal raphe 5HT cells of LepR-Cre-ChR2 mice evoked a corresponding excitatory postsynaptic current in serotonin neurons. This may be a mechanism that leptin reduces obstructive sleep apnea and maintain respiratory function in obese patients.

Research Areas

GW Expert Finder utilizes up to four primary sources that shares data to populate individual profiles. Reference these FAQs for information on how to update your GW expert profile.
GW Expert Finder utilizes up to four primary sources that shares data to populate individual profiles. Reference these FAQs for information on how to update your GW expert profile.