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Wenge Zhu Faculty Member


Wenge Zhu, Ph.D. Department of Biochemistry and Molecular Medicine The George Washington University Washington DC 20037 Office phone: 202-994-3125, Fax: 202-994-8974 E-mail: wz6812@gwu.edu EDUCATION 2003 Ph.D., Cell and Molecular Biology, University of Vermont 1990 B.S., Genetics, Nankai University, China EMPLOYMENT 2015- Associate professor (tenured), Department of Biochemistry and Molecular Medicine, George Washington University 2010-15 Assistant professor, Department of Biochemistry and Molecular Medicine, George Washington University 2007-09 IRTA Fellow, NICHD/NIH, Bethesda, MD 2003-07 Postdoc associate, University of Virginia, Charlottesville, VA 2003 Postdoc fellow, Harvard Medical School, Boston, MA PUBLICATIONS (after 2015) 1. Zhou, Y., Y.Zhang, C. Peng, Z. Li, H. Pei, H. Pei, Zhu W. And-1 O-Glycosylation regulates HR repair and radioresistance in colorectal cancer, 2021. Revision. 2. Li, J., H. Wei, Y. Zhou, Z. Li, W. Zheng, Y. Zhang, Y. Li and W. Zhu. Identification of potent SENP1 inhibitors to overcome platinum drug resistance. Clinical and Translational Medicine, 2021. In press. 3. Li, J., Y. Zhang, J. Sun, C.-W. Chen, Z. Li, D. W. Chan, R. Huang, H. Pei, W. Zheng, M. Xia and W. Zhu. Discovery and characterization of potent And-1 inhibitors for cancer treatment. Clinical and Translational Medicine, 2021, In press. 4. Zhang, Y., J. Li, Y. Zhou, Z. Li, C. Peng, H. Pei and W. Zhu. And-1 links ICL-stalled replication forks with FANCM complex for initiation of Fanconi anemia pathway " Nucleic Acids Res. 2021. Under Review 5. Li, J., R. Wu, M. M. H. Yung, J. Sun, Z. Li, H. Yang, Y. Zhang, S. S. Liu, A. N. Y. Cheung, H. Y. S. Ngan, J. C. Braisted, W. Zheng, H. Wei, Y. Gao, P. Nemes, H. Pei, D. W. Chan, Y. Li and Zhu W. SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance. Cell Death Dis, 2021, 12(4): 341. 6. Tan, W., P. Jiang, W. Zhang, Z. Hu, S. Lin, L. Chen, Y. Li, C. Peng, Z. Li, A. Sun, Y. Chen, Zhu W, Y. Xue, Y. Yao, X. Li, Q. Song, F. He, W. Qin and H. Pei. Posttranscriptional regulation of de novo lipogenesis by glucose-induced O-GlcNAcylation. Mol Cell. 2021, 81: 1890-1904 7. Hu Z, Mi S, Zhao T, Peng C, Peng Y, Chen L, Zhu W, Yao Y, Song Q, Li X, Li X, Jia C, Pei H. BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites. EMBO J. 2020, 29; e104133. PubMed PMID: 32347575. 8. Moufarrij S, Srivastava A, Gomez S, Hadley M, Palmer E, Austin PT, Chisholm S, Roche K, Yu A, Li J, Zhu W, Lopez-Acevedo M, Villagra A, Chiappinelli KB. Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer. Sci Rep. 2020; 10(1):3470. 9. Zhang Y, Li Z, Hao Q, Tan W, Sun J, Li J, Chen CW, Li Z, Meng Y, Zhou Y, Han Z, Pei H, DePamphilis ML, Zhu W. The Cdk2-c-Myc-miR-571 Axis Regulates DNA Replication and Genomic Stability by Targeting Geminin. Cancer Res. 2019; 79(19):4896-4910. 10. Li Z, Zhou W, Zhang Y, Sun W, Yung MMH, Sun J, Li J, Chen CW, Li Z, Meng Y, Chai J, Zhou Y, Liu SS, Cheung ANY, Ngan HYS, Chan DW, Zheng W, Zhu W. ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer. Clin Cancer Res. 2019; 25(19):5947-5960. 11. Zhang Y, Wu X, Kai Y, Lee CH, Cheng F, Li Y, Zhuang Y, Ghaemmaghami J, Chuang KH, Liu Z, Meng Y, Keswani M, Gough NR, Wu X, Zhu W, Tzatsos A, Peng W, Seto E, Sotomayor EM, Zheng X. Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. JCI Insight. 2019; 4(24). doi: 10.1172/jci.insight.129344. 12. Dai S, Yang S, Hu X, Sun W, Tawa G, Zhu W, Schimmer AD, He C, Fang B, Zhu H, Zheng W. 17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells. Mol Cancer Ther. 2019; 18(7):1265-1277. 13. Chen CW, Li Y, Hu S, Zhou W, Meng Y, Li Z, Zhang Y, Sun J, Bo Z, DePamphilis ML, Yen Y, Han Z, Zhu W. DHS (trans-4,4'-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2). Oncogene. 2019; 38(13):2364-2379. 14. Peng Y, Liao Q, Tan W, Peng C, Hu Z, Chen Y, Li Z, Li J, Zhen B, Zhu W, Li X, Yao Y, Song Q, Liu C, Qi X, He F, Pei H. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. Nat Commun. 2019; 10(1):1224. 15. Sun J, Cai X, Yung MM, Zhou W, Li J, Zhang Y, Li Z, Liu SS, Cheung ANY, Ngan HYS, Li Y, Dai Z, Kai Y, Tzatsos A, Peng W, Chan DW, Zhu W. miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer. Oncogene. 2019; 38(4):564-580. 16. Tian T, Wang, M, Zhu Y, Zhu W, Yang T, Li H, Lin S, Dai C, Deng Y, Song D, Li N, Zhai Z, Dai Z. Expression, Clinical Significance, and Functional Prediction of MNX1 in Breast Cancer. Mol. Ther. Nucleic Acids. 2018; 13: 399-406. 17. Sima N, Sun W, Gorshkov K, Shen M, Huang W, Zhu W, Xie X, Zheng W, Cheng X. Small molecules identified from a quantitative drug combinational screenresensitize cisplatin's response in drug-resistant ovarian cancer cells. Transl Oncol. 2018; 11: 1053-1064. 18. Tian T, Wang M, S Lin, Y Guo, Z Dai, K Liu, P Yang, C Dai, Y Zhu, Y Zheng, P Xu, Zhu W (co-corresponding), Dai Z. The Impact of lncRNA Dysregulation on Clinicopathology and Survival of Breast Cancer: A Systematic Review and Meta-analysis. Mol Ther Nucleic Acids. 2018; 12: 359–369. 19. Tian T, Wang M, Zheng Y, Yang T, Zhu W, Li H, Lin S, Liu K, Xu P, Deng Y, Zhou L, Dai Z. Association of two FOXP3 polymorphisms with breast cancer susceptibility in Chinese Han women. Cancer Management and Research. 2018; 10: 867–872. 20. Zhou W, Sun W, Yung MMH, Dai S, Cai Y, Chen CW, Meng Y, Lee JB, Braisted JC, Xu Y, Southall NT, Shinn P, Huang X, Song Z, Chen X, Kai Y, Cai X, Li Z, Hao Q, Cheung ANY, Ngan HYS, Liu SS, Barak S, Hao J, Dai Z, Tzatsos A, Peng W, Pei H, Han Z, Chan DW, Zheng W, Zhu W. Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance. Oncogene. 2018; 37(29):3981-3997 21. Meng Y, Chen CW, Yung MMH, Sun W, Sun J, Li Z, Li J, Li Z, Zhou W, Liu SS, Cheung ANY, Ngan HYS, Braisted JC, Kai Y, Peng W, Tzatsos A, Li Y, Dai Z, Zheng W, Chan DW, Zhu W. DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer. Cancer letters. 2018; 428: 04-116 22. Wang M, Tian T, Ma X, Zhu W, Guo Y, Duan Z, Fan J, Lin S, Liu K, Zheng Y, Sheng Q, Dai Z. Peng H. Genetic polymorphisms in caveolin1 associate with breast cancer risk in Chinese Hanpopulation. Oncotarget. 2017; 8(53):91654-91661. PMID: 29207674 23. Dai ZJ, Liu XH, Wang M, Guo Y, Zhu W, Li X, Lin S, Tian T, Liu K, Zheng Y, Xu P, Jin T, Li X. IL-18 polymorphisms contribute to hepatitis B virus-related cirrhosis and hepatocellular carcinoma susceptibility in Chinese population: a case-control study. Oncotarget. 2017; 8 (46):81350-81360. PMID: 29113394 24. Tian T, Wang M, Zhu W, Dai ZM, Lin S, Yang PT, Liu XH, Liu K, Zhu YY, Zheng Y, Liu M, Dai ZJ. MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis. Aging. 2017; 9:381-392. PMID: 28148887 25. Li Y, Li Z, Wu R, Han Z, Zhu W. And-1 is required for homologous recombination repair by regulating DNA end resection. Nucleic Acids Res. 2017; 45:2531-2545, PMID: 27940557 26. Lin S, Wang M, Liu X, Zhu W, Guo Y, Dai Z, Yang P, Tian T, Dai C, Zheng Y, Hu C, Wei L, Dai Z. Association of genetic polymorphisms in MIF with breast cancer risk in Chinese women. Clin Exp Med. 2016 Nov 14. PMID: 27844180 27. Vassilev A, Lee CY, Vassilev B, Zhu W, Ormanoglu P, Martin SE, DePamphilis ML. Identification of genes that are essential to restrict genome duplication to once per cell division. Oncotarget. 2016 Jun 7; 7(23):34956-76. PMID: 27144335 28. Gao L, Li D, Ma K, Zhang W, Xu T, Fu C, Jing C, Jia X, Wu S, Sun X, Dong M, Deng M, Chen Y, Zhu W, Peng J, Wan F, Zhou Y, Zon LI, Pan W. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet. 2015; 11(7):e1005346. PMID: 26131719, PMCID: PMC4488437 29. Hao J, de Renty C, Li Y, Xiao H, Kemp MG, Han Z, DePamphilis ML, Zhu W. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. EMBO J. 2015; 34(15):2096-110. PMID: 26082189, PMCID: PMC4551354

Research Areas

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