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Maho Shibata Faculty Member

Positions

Dr. Maho Shibata is an Assistant Professor at the George Washington University. She received her PhD from Cornell University, where she studied genes essential for mammalian embryonic development with Dr. Maria Garcia-Garcia, revealing tissue-specific requirements for a Kruppel-associated box (KRAB) zinc finger protein, ZFP568, and its binding partner TRIM28 in the development of extraembryonic tissues. Her interest in applying knowledge from developmental biology to cancer research led her to Dr. Michael Shen’s lab at Columbia University Medical Center, where she contributed to the establishment of an organoid culture system for studying prostate progenitor and luminal stem cells. She also examined the role of Wnt signals in mediating androgen receptor signaling to progenitor cells during prostate organogenesis. Currently, her lab is using genetically engineered mouse models, explant cultures, and 3D organoid culture systems to study androgen signaling during prostate development, and to identify novel molecular drivers of castration-resistant prostate cancer. Her broad goal is to apply knowledge and approaches from developmental biology to conduct cancer research that could lead to direct clinical benefits for prostate cancer patients.

Research Areas

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