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Marinella Gracia Temprosa Faculty Member
My research career started in 1994 at the Biostatistics Center and have included important multi-center clinical trials in the areas of neonatology, diabetes, clinical trials design, data management systems, and data visualization. I am interested in mentoring students from diverse backgrounds to help them on their way to become future researchers.
Research Areas
- Design, Analysis and Conduct of Clinical Trials
- Diabetes; CVD; Cancer; Metabolomics and other Novel Biomarker
- Empathy, Diversity and Best Practices in Team Science
- Infrastructure and Software development for Clinical Trials and Epidemiologic Studies
- Missing data, Visualization and Graphics; Longitudinal Data
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Affiliation
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Publications
selected publications
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abstract
- Buy or Build: Considerations for a robust data management system used in Phase 3 Clinical Studies 2020
- Maximizing Ascertainment of Vital and Event Occurrence over 20+ Years of Follow-up in an Aging Diverse Cohort 2020
- Effect of Metformin on Cancer Incidence over 22 years of follow-up in the Diabetes Prevention Program Outcomes Study 2020
- Per- and polyfluoroalkyl substance plasma concentrations and metabolomic markers in the Diabetes Prevention Program 2020
- Comets-Analytics: a centralized computational framework for consortia level meta-analyses 2019
- The Age Metabolome: A Consortium of Metabolomics Studies (COMETS) Meta-analysis of 91,965 adults 2019
- The Metabolome of BMI: A COnsortium of METabolomics Studies (COMETS) Meta-analysis of 85,000 adults 2019
- Benchmarks for Designing Clinical Trials with Multiple Morbidity Outcomes 2016
- COnsortium for METabolomics Studies (COMETS): Leveraging Resources to Accelerate Scientific Discovery 2016
- Associations between dietary carbohydrates and carbohydrate sub-types and diabetes risk factors in the Diabetes Prevention Program 2015
- Associations between dietary carbohydrates, carbohydrate sub-types and weight in the Diabetes Prevention Program 2015
- Effect of Long-term Interventions in the Diabetes Prevention Program (DPP) and its Outcome Study on Coronary Artery Calcium (CAC). Diabetes 2015. 2015
- Streamlining Event Adjudication: Moving from a Paper-based to Web-based System. Clinical Trials. 2015
- Regression from Pre-Diabetes to Normal Glucose Regulation is Associated with Reduction in Cardiovascular Risk: Results from the Diabetes Prevention Program Outcomes Study. Diabetes 2014 Supp 1. 2014
- Vitamin B12 Deficiency in the Diabetes Prevention Program Outcome Study (DPPOS). Diabetes. 2013
- Change in Body Mass Index is a Major Determinant of Lifestyle Induced Changes in Lipoprotein Particle Size and Number in the Diabetes Prevention Program (DPP) 2011
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academic article
- Adiposity, related biomarkers, and type 2 diabetes after gestational diabetes: The Diabetes Prevention Program. Wiley. 2021
- Long-term effects of lifestyle and metformin interventions in DPP on bone density.. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2021
- Association of Intensive Lifestyle and Metformin Interventions With Frailty in the Diabetes Prevention Program Outcomes Study. Oxford University Press (OUP). 2021
- COMETS Analytics: An online tool for analyzing and meta-analyzing metabolomics data in large research consortia.. American journal of epidemiology. 2021
- Hepatic Fat in Participants With and Without Incident Diabetes in the Diabetes Prevention Program Outcome Study.. The Journal of clinical endocrinology and metabolism. 2021
- Per- and polyfluoroalkyl substance plasma concentrations and metabolomic markers of type 2 diabetes in the Diabetes Prevention Program trial.. International journal of hygiene and environmental health. 2021
- Predictive utilities of lipid traits, lipoprotein subfractions and other risk factors for incident diabetes: a machine learning approach in the Diabetes Prevention Program.. BMJ open diabetes research care. 2021
- Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Programme. Wiley. 2021
- Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program. BMJ. 2020
- Diet quality, weight loss, and diabetes incidence in the Diabetes Prevention Program (DPP). Springer Science and Business Media LLC. 2020
- The Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures. American Diabetes Association. 2020
- Long-term metformin adherence in the Diabetes Prevention Program Outcomes Study. BMJ. 2020
- Is low-level viraemia associated with serum lipid profiles among HIV controllers?. HIV medicine. 2020
- Infertility, Gravidity, and Risk Of Diabetes among High-Risk Women in the Diabetes Prevention Program Outcomes Study.. The Journal of clinical endocrinology and metabolism. 2020
- Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program. Public Library of Science (PLoS). 2020
- Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program.. Diabetes. 2019
- Does diabetes prevention translate into reduced long-term vascular complications of diabetes?. Diabetologia. 2019
- Long-term Effects of Metformin on Diabetes Prevention: Identification of Subgroups That Benefited Most in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study.. Diabetes care. 2019
- Sex Hormones and Measures of Kidney Function in the Diabetes Prevention Program Outcomes Study.. The Journal of clinical endocrinology and metabolism. 2019
- The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies 2019
- Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS). Metabolites. 2019
- Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions.. Diabetologia. 2019
- A High-Carbohydrate, High-Fiber, Low-Fat Diet Results in Weight Loss among Adults at High Risk of Type 2 Diabetes.. The Journal of nutrition. 2017
- Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study.. Diabetologia. 2017
- Effect of Long-Term Metformin and Lifestyle in the Diabetes Prevention Program and Its Outcome Study on Coronary Artery Calcium. 2017
- Clinical Trials Targeting Aging and Age-Related Multimorbidity.. The journals of gerontology. Series A, Biological sciences and medical sciences. 2017
- Effect of Long-term Metformin and Lifestyle in the Diabetes Prevention Program and its Outcome Study on Coronary Artery Calcium 2017
- Statin use and risk of developing diabetes: results from the Diabetes Prevention Program.. BMJ open diabetes research care. 2017
- Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program 2016
- Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab. 2016
- Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study. Lancet Diabetes and Endocrinology. 2015
- Lifestyle and metformin interventions have a durable effect to lower CRP and tPA levels in the Diabetes Prevention Program except in those who develop diabetes. Diabetes Care. 2014
- Regression from Pre-diabetes to Normal Glucose Regulation is Associated with Reduction in Cardiovascular Risk: Results from the Diabetes Prevention Program Outcomes Study. Diabetes. 2014
- Confirming Glycemic Status in the Diabetes Prevention Program: Implications for Diagnosing Diabetes in High Risk Adults. Journal Of Diabetes And Its Complications. 2013
- Lifestyle and Metformin Treatment Favorably Influence Lipoprotein Subfraction Distribution in the Diabetes Prevention Program. J Clin Endocrinol Metab. 2013
- Long term effects of the Diabetes Prevention Program’s interventions on cardiovascular risk factors: a report from the DPP Outcomes Study. Diabetic Medicine. 2013
- Metabolic Syndrome Components and Their Response to Lifestyle and Metformin Interventions are Associated with Differences in Diabetes Risk in Persons with Impaired Glucose Tolerance. Diabetes Obes Metab. 2013
- Effect of progression from impaired glucose tolerance to diabetes on cardiovascular risk factors and its amelioration by lifestyle and metformin intervention: the Diabetes Prevention Program randomized trial by the Diabetes Prevention Program Research Group. Diabetes Care. 2009
- Evaluating the accuracy of an aneroid sphygmomanometer in a clinical trial setting. American journal of hypertension. 2009
- The association among autonomic nervous system function, incident diabetes, and intervention arm in the Diabetes Prevention Program. Diabetes care. 2006
- Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program. Diabetes care. 2005
- Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. Diabetes. 2005
- The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Annals of internal medicine. 2005
- Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996 2001
- Dexamethasone therapy increases infection in very low birth weight infants 1999
- Infections Among Very Low Birthweight Infants Enrolled in the NICHD Neonatal Research Network Dexamethasone (Dex) Trial• 1482. Pediatric Research. 1998
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chapter
- Role of Metformin in Global Diabetes Prevention. Metformin 60 years of Clinical Experience. 2017
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conference paper
- Dynamic Manuscript Development and Tracking of Scientific Productivity and Impact 2018
- Effect of metformin on diabetes prevention at 15 years: identification of subgroups most likely to benefit. Diabetes Prevention Program (DPP) Research Group 2017
- Make Big Data Alive: Interactive Data Visualization in Metabolomics Research 2017
- CometsAnalytics: A user-friendly web application for data harmonization and self-service cohort analysis: A user-friendly web application for data harmonization and self-service cohort analysis 2016
- Applying Acceptance Sampling, Risk-Based Monitoring, and Paperless Support to Improve Effectiveness in Data Audit Visits 2014
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conference poster
- LATINOS WITH HIV IN DC: AN INTERSECTIONAL APPROACH EXPLORING HIV HEALTH OUTCOMES 2022
- Baseline Metabolite profiles of incident diabetes and heterogeneity of treatment effect in the Diabetes Prevention Program 2019
- Metabolite profiles of incident diabetes in the Diabetes Prevention Program 2019
- The Diabetes Prevention Program Outcomes Study (DPPOS): Contributions and limitations in approaching health disparities research 2018
- Metformin and Lifestyle Interventions in DPP Do Not Have Long-term Effects on Bone Density or Falls 2018
- Real Time Monitoring of Medical Events and Adjudication in the Diabetes Prevention Program Outcomes Study (DPPOS) 2018
- Sex hormones and development of chronic kidney disease in the Diabetes Prevention Program Outcomes Study (DPPOS) 2018
- Streamlining the Protocol Oversight Program for Maximum Efficiency in the Diabetes Prevention Program Outcomes Study (DPPOS) 2018
- Make Big Data Alive: Interactive Data Visualization in Metabolomics Research 2017
- COnsortium for METabolomics Studies (COMETS): Developing Resources to Accelerate Scientific Discovery 2017
- Hepatic Fat (HF) in Prediabetes (PreDM) and Diabetes (DM) in the Diabetes Prevention Program and Outcome Study (DPPOS) 2017
- Interventions Modify Associations Between Biomarkers and Incident Diabetes in the Diabetes Prevention Program 2017
- Make Big Data Come Alive: Interactive Data Visualization in Metabolomics Research 2017
- Utilizing Remote Participant Visits to Boost Retention in a Long-term Clinical Trial 2017
- Implementing Electronic Patient Reported Outcomes (ePRO) in a Long-term Trial with an Aging and Diverse Population 2017
- COnsortium for METabolomics Studies (COMETS): leveraging resources to accelerate scientific discovery 2017
- Interactive Data Visualization in Metabolomics Research 2017
- COMETS Analytics: A user-friendly web application for data harmonization and self-service cohort analysis 2016
- COnsortium for METabolomics Studies (COMETS): Leveraging Resources to Accelerate Scientific Discovery 2016
- Considerations and Challenges for Transition to Mobile Electronic Patient Reported Outcomes (ePRO) in a Long-term Trial with an Aging and Diverse Population 2016
- . 7 Steps to Edit Heaven: An Automated Workflow Data Edit Implementation Process in Multicenter Clinical Trials 2014
presentations
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presentation
- GW School of Public Health Celebration of Bicentennial, GWU 2021
- Worldwide Statistics Without Borders Projects: Statistics, Data Visualization, and Decision Making — Invited Panel, Joint Statistical Meetings 2018 2018
- Power analyses for DPPOS Phase 3, Diabetes Prevention Program Outcomes Study Steering Committee 2015
- ADA Symposium, Future plans of DPPOS 2014
- An Imputation-Estimation Algorithm Using Time-Varying Auxiliary Covariates for a Longitudinal Model When Outcome is Missing by Design, Seminar 2013
- Vitamin B12 Deficiency in the Diabetes Prevention Program Outcome Study, Poster tour 2013
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Research
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Service
reviewer of
- .S. Army Medical Research and Materiel Command, Congressionally Directed Medical Research Programs (Journal)
- 2015/05 ZDP1 EEO (11) R Panel 11 DP15-002 Population-Based Diabetes in Youth Registry (Journal)
- American Journal of Preventive Medicine (Journal)
- BMJ Open (Journal)
- Frontiers in Epidemiology (Journal)
- Journal of the Academy of Nutrition and Dietetics (Journal)
- Journal of the National Cancer Institute (Journal)
- NHS UK (Journal)
- NIH - NEI Special Emphasis Panel (Journal)
- NIH - NEI Special Emphasis Panel (Journal)
- NIH OSMB for RECOVER (Researching COVID to Enhance Recovery) (Journal)
- NIH PASC SEP review (Journal)
- NIH Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) (Journal)
- NIH Psychosocial Risk and Disease Prevention (PRDP) Study Section (Journal)
- NIH Study Section Ad Hoc Reviewer (Journal)
- NIH-NCI SEP Cancer Prevention Clinical Trials Network (CP-CTNet): Data Management, Auditing, and Coordinating Center (DMACC) (Journal)
- NIH-NEI DSMB for Descemet Endothelial Thickness Comparison Trial (DETECT) (Journal)
- NIH-NEI Diabetic Retinopathy Clinical Research Network (Journal)
- NIH-NHLBI DSMB for Precisions Trial (Journal)
- NIH-NHLBI DSMB for Pulmonary Trials Cooperative (Journal)
- NIH-NHLBI Enrich Special Emphasis Panel (Journal)
- NIH-NHLBI OSMB for Primero Study (Puerto Rican Infant Metagenomic and Epidemiologic study of Respiratory Outcomes) (Journal)
- NIH-NHLBI SARS CoV2/COVID-19 Protocol Review Committee (Journal)
- NIH-NHLBI Special Emphasis Panel (Journal)
- NIH-NIA DSMB Member for Pharm DC (Journal)
- NIH-NIA SEP for Diet and Aging (Journal)
- NIH-NIA Special Emphasis Panel (Journal)
- NIH-NICHD Special Emphasis Panel (Journal)
- NIH-NIDCD COVID SEP (Journal)
- NIH-NIDCD SEP For Cooperative Agreement for Clinical Trials in Communication Disorders (Journal)
- NIH-NIHMD review panel (Journal)
- Nature Scientific Reports (Journal)
- Nature Scientific Reports (Journal)
- PLOS ONE (Journal)
- Site Visit to Coordinating Center of NHLBI INternational Childhood Cardiovascular Cohort Consortium (I3C) (Journal)
- Special Emphasis Panel/Scientific Review Group 2014/10 ZDK1 GRB-1 (O2) (Journal)
professional service activities
- Sigma Xi Member 2020 -
- American Association for the Advancement of Science Member 2018 -
- American Association for Cancer Research Member 2017 -
- Metabolomics Association of North America Member 2018 - 2199
- Metabolomics Society Member 2016 - 2199
- missing activity Member 2010 - 2199
- International Biometrics Society and ENAR Member 2009 - 2199
- American Diabetes Association Member 2002 - 2199
- Society for Clinical Trials Member 1998 - 2199
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Background
awards and honors
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Contact
full name
- Marinella Gracia Temprosa
mailing address
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Biostatistics Center
6110 Executive Blvd Suite 750
Rockville, MD 20852
USA
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